The Hand are a death-cult of ninjas who were formed to do the bidding of a demon known as The Beast.
In Earth-1068, they have had numerous encounters with Daredevil and Wolverine.
They currently serve an unknown master, and are apparently allied with both Hydra and AIM to launch coordinated attacks on various targets.
The Hand somehow managed to kidnap Wolverine and use some form of magic to enslave and compel him to attach the SHIELD Helicarrier in an apparent suicide mission. (Assembly Required #1)